Hello Charlotte Habegger-Polomat,
I am not an expert modeller user, but what I can "share" about it?
I think the number of models generated depends on available time and
computational power you have to carry it. I usually generate between 100 and
200, and select that model with the lowest "current energy".
Probably somebody could discuss it better, anyway, I tried ;)
Frederico Arnoldi
UNESP - Rio Claro - Brazil
>
>Dear Modeller users,
>
>I was wondering if others would share how many structures you usually
>generate for a family of models.
>
>I am currently working on modelling my protein of interest with 3 known
>template structures (>30% sequence similarity). When using Modeller, I
>generate a family of 20 models and then evaluate the variability and
>quality of models within the family.
>
>How many do other Modeller users generate?
>
>How do you decide on this number?
>
>I've read articles where 3 models, others where 30 models were generated
>with Modeller...
>
>Thanks!
>
>-Charlotte Habegger-Polomat