[modeller_usage] Using modeller for checking metagenomic distant homologs
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Subject: [modeller_usage] Using modeller for checking metagenomic distant homologs
From: Ben Temperton <>
Date: Tue, 19 Jan 2010 21:34:56 +0000
Hi there,
I am currently writing a pipeline to identify distant homologs of genes in metagenomic samples using HMMER 3.0 and hmm models of conserved domains from Pfam.
Once I have identified putative homologs, I would like to verify that these homologs are indeed homologs by threading them onto a known protein structure and evaluating whether the threading was successful.
Given I'm very new to protein threading, is Modeller an ideal tool to use for this application?