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Re: [modeller_usage] weighting restraints

On 05/04/2010 03:50 PM,  wrote:

having multiple templates, I want to weight template based restraints
down with respect to other (stereochemical) restraints. Is it then
more sensible to weight down the template based restraints (weight<
1, weight=1 for rest) or to weight up the other restraints (weight>
1, weight=1 for rest)? Does it make any difference for the (simulated
annealing) optimization scheme (because the "scale" is changed)?
No, it makes no difference. The weights are all relative, so either of your schemes should work. 

	Ben Webb, Modeller Caretaker
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