C; family: aspartic proteinase
C; class: all beta
C; The datasets XREN and XYPA are gifts from T. Blundell
>P1;Xypa
structureX:Xypa:  -1 : : 326 : :proteinase A:Saccharomyces cerevisiae: 2.50:21.00
--GGHDVPLTNYL--N-AQYYTDITLGTPPQNFKVILDTGSSNLWVPSNECG--SLACFLHSKYDHEASSSYKAN
-GTEFAIQYGT-GSLEGYISQDTLSI------------GDLTIPKQDFAEATSEPGLTFAFG------KFDGILGLGYDTISV
D------KVVPPFYNAIQQDLLDEKRFAFYLGDTSKDTENGGEATFGGIDESKFKGDITWLPVRR----KAYWEV
KFEGIGLGDEYA-ELES-HGAAIDTGTSLITLPSGLAEMINAEI--GAKKGW-TGQYTLDCNTRDNL-PDLIFNF
-----NGYNFTIGPYDYTLEV-----SGSCISAITPMDFPEPVGPLAIVGDAFLRKYYSIYDIG-NNAVGLAKAI
------*
>P1;Xren
structureX:Xren:  -2 :A: 326 :A:renin:Mus musculus: 1.80:19.60
ADLISPVVLTNYL--N-SQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMEN
-GDDFTIHYGS-GRVKGFLSQDSVTV------------GGITV-TQTFGEVTQLPLIPFMLA------QFDGVLGMGFPAQAV
G------GVTPVFDHILSQGVLKEKVFSVYYNRGP--ALLGGEVVLGGSDPQHYQGDFHYVSLSK----TDSWQI
TMKGVSVGSSTLLCEEG-CEVVVDTGSSFISAPTSSLKLIMQAL--GAAEKRL-HEYVVSCSQVPTL-PDISFNL
-----GGRAYTLSSTDYVLAA/----AKLCTVALHAMDIPPPTGPVWVLGATFIRKFYTEFDRH-NNRIGFALAR
------*
>P1;1bbs
structureX:1bbs:  -1 : : 326 : :renin:Homo sapiens: 2.80:19.60
--TTSSVILTNYM--D-TQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHN
-GTELTLRYST-GTVSGFLSQDIITV------------GGITV-TQMFGEVTEMPALPFMLA------EFDGVVGMGFIEQAI
G------RVTPIFDNIISQGVLKEDVFSFYYNRDSA/--LGGQIVLGGSDPQHYEGNFHYINLIK----TGVWQI
QMKGVSVGSSTLLCEDG-CLALVDTGASYISGSTSSIEKLMEAL--GAKKRLF--DYVVKCNEGPTL-PDISFHL
-----GGKEYTLTSADYVFQESYS-SKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRR-NNRIGFALAR
------*
>P1;1lya
structureX:1lya:   1 :A: 346 :B:cathepsin D:Homo sapiens:  2.50: 18.80
--GPIPEVLKNYM--D-AQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKN
-GTSFDIHYGS-GSLSGYLSQDTVSVPCQ/--------GGVKVERQVFGEATKQPGITFIAA------KFDGILGMAYPRISV
N------NVLPVFDNLMQQKLVDQNIFSFYLSRDPDA-QPGGELMLGGTDSKYYKGSLSYLNVTR----KAYWQV
HLDQVEVASGLTLCKEG-CEAIVDTGTSLMVGPVDEVRELQKAI--GAVPLIQ-GEYMIPCEKVSTL-PAITLKL
-----GGKGYKLSPEDYTLKVSQA-GKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRD-NNRVGFAEAA
------*
>P1;5pep
structureX:5pep:   1 : : 327 : :pepsin:Sus scrofa: 2.30:18.00
---IGDEPLENYL--D-TEYFGTIGIGTPAQDFTVIFDTGSSNLWVPSVYCS--SLACSDHNQFNPDDSSTFEAT
-SQELSITYGT-GSMTGILGYDTVQV------------GGISDTNQIFGLSETEPGSFLYYA------PFDGILGLAYPSISA
S------GATPVFDNLWDQGLVSQDLFSVYLSSNDD---SGSVVLLGGIDSSYYTGSLNWVPVSV----EGYWQI
TLDSITMDGETIACSGG-CQAIVDTGTSLLTGPTSAIANIQSDI--GASENS-DGEMVISCSSIASL-PDIVFTI
-----NGVQYPLSPSAYILQDD-----DSCTSGFEGMDVPTSSGELWILGDVFIRQYYTVFDRA-NNKVGLAPVA
------*
>P1;4cms
structureX:4cms:  -2 : : 326 : :chymosin:Bos taurus: 2.20:15.80
-GEVASVPLTNYL--D-SQYFGKIYLGTPPQEFTVLFDTGSSDFWVPSIYCK--SNACKNHQRFDPRKSSTFQNL
-GKPLSIHYGT-GSMQGILGYDTVTV------------SNIVDIQQTVGLSTQEPGDVFTYA------EFDGILGMAYPSLAS
E------YSIPVFDNMMNRHLVAQDLFSVYMDRNG----QESMLTLGAIDPSYYTGSLHWVPVTV----QQYWQF
TVDSVTISGVVVACEGG-CQAILDTGTSKLVGPSSDILNIQQAI--GATQNQ-YGEFDIDCDNLSYM-PTVVFEI
-----NGKMYPLTPSAYTSQD-----QGFCTSGFQSE/------QKWILGDVFIREYYSVFDRA-NNLVGLAKAI
------*
>P1;1mpp
structureX:1mpp:  -1 : : 332 : :pepsin:Mucor pusillus: 2.10:16.20
--GSVDTPGLYDF--DLEEYAIPVSIGTPGQDFYLLFDTGSSDTWVPHKGCDNS-EGCVGKRFFDPSSSSTFKET
-DYNLNITYGT-GGANGIYFRDSITV------------GGATVKQQTLAYVDNVSG-PTAEQSPDSELFLDGIFGAAYPDNTA
MEAEYGDTYNTVHVNLYKQGLISSPVFSVYMNTND----GGGQVVFGGVNNTLLGGDIQYTDVLKSRGGYFFWDA
PVTGVKIDGSDAVSFDGAQAFTIDTGTNFFIAPSSFAEKVVKAALPDATESQ--QGYTVPCSKYQDSKTTFSLVL
QKSGSSSDTIDVSVPISKMLLPVDKSGETCMFIVLP-DG----GNQFIVGNLFLRFFVNVYDFG-KNRIGFAPLA
SGYEND*
>P1;4ape
structureX:4ape:  -2 : : 326 : :endothiapepsin:Endothia parasitica: 2.10:17.80
--STGSATTTPIDSLD-DAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETT--ASEVDGQTIYTPSKSTTAKLL
SGATWSISYGDGSSSSGDVYTDTVSV------------GGLTVTGQAVESAKKVSS-SFTEDS-----TIDGLLGLAFSTLNT
VSP---TQQKTFFDNAKA--SLDSPVFTADLGYH-----APGTYNFGFIDTTAYTGSITYTAVSTK---QGFWEW
TSTGYAVGSGTFKSTS--IDGIADTGTTLLYLPATVVSAYWAQV-SGAKSSSSVGGYVFPCSA--TL-PSFTFGV
G-----SARIVIPGDYIDFGPIS-TGSSSCFGGIQSSAGI----GINIFGDVALKAAFVVFNGATTPTLGFASK-
------*
>P1;3app
structureX:3app:   1 : : 323 : :penicillopepsin:Penicillium janthinellum: 1.80:13.60
-AASGVATNTPTA-ND-EEYITPVTIG--GTTLNLNFDTGSADLWVFSTELP--ASQQSGHSVYNPSAT--GKEL
SGYTWSISYGDGSSASGNVFTDSVTV------------GGVTAHGQAVQAAQQISA-QFQQDT-----NNDGLLGLAFSSINT
VQP---QSQTTFFDTVKS--SLAQPLFAVALKHQ-----QPGVYDFGFIDSSKYTGSLTYTGVDNS---QGFWSF
NVDSYTAGSQ-SG-DG--FSGIADTGTTLLLLDDSVVSQYYSQV-SGAQQDSNAGGYVFDCST--NL-PDFSVSI
S-----GYTATVPGSLINYGPSGD--GSTCLGGIQSNSGI----GFSIFGDIFLKSQYVVFDSD-GPQLGFAPQA
------*
>P1;2apr
structureX:2apr:   1 : : 325 : :rhizopuspepsin:Rhizopus chinensis: 1.80:14.30
-AGVGTVPMTDYG-ND-IEYYGQVTIGTPGKKFNLDFDTGSSDLWIASTLCT---NCGSGQTKYDPNQS-STYQA
DGRTWSISYGDGSSASGILAKDNVNL------------GGLLIKGQTIELAKREAA-SFASG------PNDGLLGLGFDTITT
V-----RGVKTPMDNLISQGLISRPIFGVYLGKAKN--GGGGEYIFGGYDSTKFKGSLTTVPIDNS---RGWWGI
TVDRATVGTSTVA-SS--FDGILDTGTTLLILPNNIAASVARAY--GASDNG-DGTYTISCDT-SAF-KPLVFSI
N-----GASFQVSPDSLVFEEF----QGQCIAGFGY-GNW----GFAIIGDTFLKNNYVVFNQG-VPEVQIAPVA
E-----*