Re: [IMP-users] protein structure generation from sequences with IMP

On 04/10/2012 12:40 PM, Adhikari, Badri (MU-Student) wrote: > We are working on a project in which we need to generate protein models > from the amino acid sequences, using IMP.

If you want to build extended chain structures, see http://salilab.org/imp/nightly/doc/html/atom_examples.html#structure_from_se...

If you have some extra knowledge (e.g. stereochemistry, atom-atom distances) you can then add that in as restraints and sample.

If you want to build homology models, IMP doesn't do that - you can use our MODELLER package to do that instead.

If you want to build ab initio models, you might want to try a tool like Rosetta.

Ben