Hi Modeller developers and friends,
in Sanchez and Sali 1997 Curr Opin Struct Biol 7:206-214 I read that a possible way to improve on homology modeling below 30 PID could be "iterative changes in the alignment during caluclation" My question is: Is this a great idea that has been realized already and I just missed where and how, is it work in progress or has it been discarded again due to technical problems? Could one, alternatively, if only one template is availble, use this template several times with different alignment variants (home-made version of modeling on several templates, so to speak) so that different homology derived restraints go into the same VTF, or is it, at present knowledge, better to go for ensembles of models and then try to construct one or more "best" consensus models? Any and all information and ideas are much appreciated! margot
-- Dr. Margot Ernst Abteilung Prof. Sieghart Institut f. Hirnforschung Spitalgasse 4 A-1090 WIEN margot.ernst@univie.ac.at visit brainresearch: www.univie.ac.at/brainresearch