3 Oct
2011
3 Oct
'11
10:52 a.m.
On 09/12/2011 06:27 AM, Ashish Runthala wrote: > I am finding a critical difference in the pairwise alignment > computed by MODELLER and the corresponding alignment cognitive to the > CS-BLAST undertaken alignment.
That doesn't seem surprising. BLAST alignments are local and approximate; Modeller does rigorous dynamic programming with global or local alignments using a range of methods for constructing the residue distance matrix.
> Where CS-BLAST has got the altered sequences from, when i precisely > called the PDB for it.
You'll have to ask the CS-BLAST people about that.
Ben Webb, Modeller Caretaker
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