Dear all,

I have a protein-A of about 1200 amino acids. The residue from 700-900 is responsible for the protein to be in its active state. There is a template which has this region in the active form, while the other portions are disordered. I would like to know if it is possible to model just this residue 700-900 with respect to my template to get it into the active form. If yes, should I use the whole protein template or the region corresponding to the one which I want to model in my target protein? Also after modelling this residues, How could I combine this back to the rest of the target protein. Thank you for any help provided.

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