Hi there,<div><br></div><div>I am currently writing a pipeline to identify distant homologs of genes in metagenomic samples using HMMER 3.0 and hmm models of conserved domains from Pfam.</div><div>Once I have identified putative homologs, I would like to verify that these homologs are indeed homologs by threading them onto a known protein structure and evaluating whether the threading was successful.</div>
<div>Given I&#39;m very new to protein threading, is Modeller an ideal tool to use for this application? </div><div><br></div><div>Many thanks,</div><div><br></div><div>Ben Temperton<br><div><br></div><div><br></div></div>