Hi,
I have question that may sound a little naive. It has more to do with homology modeling than modeller itself. Here's the question:
Since, through homology modeling it is possible to model the structure of a molecule, given the structure of another molecule that is fairly similar,isn't it possible theoretically, then, to be able to model the structure of any protein in that manner? Why isn't it possible to used a modelled structure as a template for further modelling?
For example: we could start with an accurate structure of some protein molecule, change a few residues and then model the mutant. Then use the mutant as a template, change some more residues and then model it. In this way isn't it possible, theoretically, to model any protein? What are the practical problems with this idea?
Thanks, Chandrika