On 4/29/15 8:08 PM, Debajyoti Dutta wrote: > The protein i want to model has 12 transmembrane helices. The topology > of the protein is known from an distantly related protein structure. > among the 12 transmembrane domains, 5 trnasmembrane helices structures > (each helix separate PDB structure) are known determined using NMR. I > wonder if it is possible to model the protein based on the hybrid method > (using the structural information available).

I'm not sure what you're asking here but you could certainly model such a system (at least the 5 helices for which structures are available) using multiple templates.

Ben Webb, Modeller Caretaker