Dear Modellers,

I have a monomer sequence A1 that is homologous to the monomer of a multimer structurer B1....BN. I want to build a model of the multimer B1....BN with modeller. I can think of two ways ot do this:

1. Divide the pdb files of the multimers B1....BN into single pdb files. Then I build models on A1...AN matched to them. Then I merge the A1...AN PDB files to get A1...AN.

2. Model A1 against B1. strcuturally align the structure of A1 against B1...BN.

My question: is there any way that I can build the multimer A1...AN in one step against B1...BN?

Thanks and best wishes, Rich -------------------------------------------------------------- Richard A. Friedman, PhD Associate Research Scientist Herbert Irving Comprehensive Cancer Center Oncoinformatics Core Lecturer Department of Medical Informatics Box 95, Room 130BB or P&S 1-420C Columbia University 630 W. 168th St. New York, NY 10032 (212)305-6901 (5-6901) (voice) friedman@cancercenter.columbia.edu http://cancercenter.columbia.edu/~friedman/

"I wish that all homework was a drawing contest". -Rose Friedman, age 6