modelling protein protein interaction
Dear friends, I have built a quick model of a mutant. the protein is a homodimer mutation in one chain produces a heterodimer
how can I minimize the protein protein interaction site of the heterodimer?
can I adapt one of the py files that are provided among the examples when downloading modeller?
thank you
mv
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On 07/27/2015 05:45 AM, MARIA VITTORIA CUBELLIS wrote: > I have built a quick model of a mutant. > the protein is a homodimer > mutation in one chain produces a heterodimer > > how can I minimize the protein protein interaction site of the heterodimer?
Modeller doesn't model protein-protein interactions. You can certainly build a model of your heterodimer though using the homodimer as a template (you don't need to do anything special).
Ben Webb, Modeller Caretaker
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MARIA VITTORIA CUBELLIS -
Modeller Caretaker