How to generate Homology models using a computer farm
Dear All,
In order to build several models of a target protein, we are running the same Python script on different computers at the same time. In this case, the script is the same and the proteins used as models are also the same.
At the first attempt we expected to build different models and then assess them, and choose the best one or change your alignment/template if none of the models are acceptable.
However when these models were evaluated, we discovered that MODELLER has built the same models, in the same order on all computers.
I want know whether exist some parameters that could be adjusted at the Python script, (a kind of random number generator ?) in order to assure that different sets of models will be generate on each computer?
Regards,
Caio Veloso
On 5/10/10 1:19 PM, Caio Veloso wrote: > In order to build several models of a target protein, we are running > the same Python script on different computers at the same time. ... > we discovered that MODELLER has built the same models, in the same > order on all computers.
Indeed, because Modeller is deterministic, and gives reproducable results.
> I want know whether exist some parameters that could be adjusted at > the Python script, (a kind of random number generator ?) in order to > assure that different sets of models will be generate on each > computer?
You need to set rand_seed to a different value on each machine - something like -2 - (number of machine) should do the trick: http://salilab.org/modeller/9v8/manual/node110.html
Ben Webb, Modeller Caretaker
participants (2)
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Caio Veloso
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Modeller Caretaker