Hello,

I have a general question on Comparative Protein Modeling.

Is the modeling of only the active site residues, having a seq. identity of 80% with another sequence of a 3D structure, better than modeling the entire protein (seq. identity ~ 50%)? What are the disadvantages of modeling only certain seqments of a protein, active site mainly? When is this desirable rather than modeling the entire protein?

Thank you.

Kind regards, Yogesh

Yogesh Sabnis Ph.D Dept. Medicinal Chemistry Uppsala University BMC, Box 574 Uppsala, SE-753 31 Sweden

Phone: 0046 (0)18 4715012 Fax: 0046 (0)18 4714474