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Integrative structures of the human Cop9 signalosome

Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling PubMed logo PDB-Dev

tickVerified to work with the latest stable IMP release (2.13.0). The files are also available at GitHub.
Additional software needed to use these files: IMP numpy MODELLER install instructions

Anaconda logo To install the software needed to reproduce this system with the Anaconda Python command line tool (conda), run the following commands:

conda config --add channels salilab
conda install imp numpy modeller

UCSF logo To set up the environment on the UCSF Wynton cluster to run this system, run:

module load Sali
module load imp python3/numpy modeller
Tags chemical crosslinks MODELLER PMI X-ray

DOI

These scripts demonstrate the use of IMP in the modeling of the Cop9 Signalosome (CSN) complex using multi-crosslinking datasets. The scripts work with the IMP (Release 2.8.0).

List of files and directories:

Information

Author(s): Ilan E. Chemmama

License: CC BY-SA 4.0 This work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International License.

Last known good IMP version: build info build info

Publications: Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling.
Craig Gutierrez*, Ilan E. Chemmama*, Haibin Mao, Clinton Yu, Ignacia Echeverria, Sarah A. Block, Scott D. Rychnovsky, Ning Zheng, Andrej Sali, Lan Huang
Proceedings of the National Academy of Sciences Feb 2020, 117 (8) 4088-4098; DOI: 10.1073/pnas.1915542117.
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