Hi,
I am trying to model an antibody variable region using Modeller. I have two
questions :
1. I have modelled the heavy chain and Light chain seperately. Now, how can
I orient this two chains to generate the complete molecule?
2. CDR loops of antibodies have specific canonical structures, which
depends upon loop length, hydrogen bond ladder etc. Can I modify Modeller
to build the loops as per the canonical structures?
With regards
Biplab
--
Biplab Bose, Ph. D
Lecturer,
Biological Sciences Group,
Birla Institute of Technology & Science (BITS), Pilani,
Rajasthan, INDIA
PIN-333031
Ph.# 9828717874
http://www.biplabbose.wb.sthttp://www.bits-pilani.ac.inBITS, Pilani