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[modeller_usage] How to deal with a part of protein sequence that have no alignment with the template
To : modeller_usage <modeller_usageATsalilab.org >
Subject : [modeller_usage] How to deal with a part of protein sequence that have no alignment with the template
From : xiazhendong1986 <xiazhendong1986AT163.com >
Date : Mon, 28 Sep 2009 16:03:03 +0800 (CST)
alignment: _aln.pos 10 20 30 40 50 60 1kv9A -------------------------------------------------------------------- 1yiqA -------------------------------------------------------------------- 1kb0A -------------------------------------------------------------------- sldha MRRPYLLATAAGLALACSPLIAHAQFAPAGAGGEPSSSVPGPGNASEPTENSPKSQSYFAGPSPYAPQ _consrvd
_aln.p 70 80 90 100 110 120 130 1kv9A ------------AGVDEAAIRATEQ------AGGEWLSHGRTYAEQRFSPLKQIDASNVRSLGLAWYM 1yiqA --------ADIPANVDGARIIAADK------EPGNWMSTGRTYDEQRYSPLKQISDQNVGQLGLAWSY 1kb0A -TGPAAQAAAAVQRVDGDFIRANAA------RTPDWPTIGVDYAETRYSRLDQINAANVKDLGLAWSY sldha APGVNAANLPDIESIDPSQVPAMAPQQSANPARGDWVAYGRDDHQTRYSPLSEITPENASKLKVAFVY _consrvd * * * * * * * * * * *
As we can see from above, the templates have no sequence from amino 1 to 70 to align with the target protein "sldha", and the modelling result is that the structure of sequence 1-70 is a just a long chain with no fold. So how can I get the structure of sequence 1-70?
Best wishs.
James
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