Re: [modeller_usage] measure protein stability

[Modeller Caretaker <>]

On 11/26/2010 01:39 PM, Knut J Bjuland wrote:
> I have designed a homolog protein with sequence identity above 90 %? How
> can I measure protein stabilty and it ability to form aggreation. An
> example would be amyloid plage which aggregat in Alzheimer disease?
> Can I use dope score to measure protein stability or should I turn to
> rosetta desginer?

The DOPE score will tell you how native-like your protein is (i.e. how 
"similar" it is to known crystal structures). So it won't necessarily 
tell you whether your protein is "stable".

	Ben Webb, Modeller Caretaker
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