On 11/26/2010 01:39 PM, Knut J Bjuland wrote:
I have designed a homolog protein with sequence identity above 90 %? How can I measure protein stabilty and it ability to form aggreation. An example would be amyloid plage which aggregat in Alzheimer disease? Can I use dope score to measure protein stability or should I turn to rosetta desginer?
The DOPE score will tell you how native-like your protein is (i.e. how "similar" it is to known crystal structures). So it won't necessarily tell you whether your protein is "stable".
Ben Webb, Modeller Caretaker -- modeller-care@salilab.org http://www.salilab.org/modeller/ Modeller mail list: http://salilab.org/mailman/listinfo/modeller_usage