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Re: [modeller_usage] measure protein stability
- To: Knut J Bjuland <knutjbj AT hotmail.com>
- Subject: Re: [modeller_usage] measure protein stability
- From: Modeller Caretaker <modeller-care@ucsf.edu>
- Date: Mon, 29 Nov 2010 10:48:27 -0800
- Cc: modeller usage <modeller_usage@listsrv.ucsf.edu>
On 11/26/2010 01:39 PM, Knut J Bjuland wrote:
I have designed a homolog protein with sequence identity above 90 %? How
can I measure protein stabilty and it ability to form aggreation. An
example would be amyloid plage which aggregat in Alzheimer disease?
Can I use dope score to measure protein stability or should I turn to
rosetta desginer?
The DOPE score will tell you how native-like your protein is (i.e. how
"similar" it is to known crystal structures). So it won't necessarily
tell you whether your protein is "stable".
Ben Webb, Modeller Caretaker
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