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Hello, I am interested in using Modeller for predicting the structure of
the G protein-coupled receptor I study. This protein does not have any
homologous proteins in the PDB database and there is no experimental data to
help model the protein. Knowing this, can Modeller provide an accurate
structure of my protein to use in molecular dynamics simulations? I
understand that I can choose other crystallized GPCRs to use as templates, but
I am concerned that since Modeller is a homology modeling program that the end
model would simply look like my protein forced onto the template structure. If anyone can give me some further insight on this manner, I would greatly appreciate it. Thanks in advance for your help! Sincerely, Maggie |