Re: [modeller_usage] Is the DOPE score good for evaluating transmembrane proteins model-structures?

[Modeller Caretaker <>]

On 12/7/12 7:08 AM,  wrote:
> I was wondering whether I can use the DOPE score to evaluate models of
> transmembrane proteins?

The DOPE score is a statistical potential. As such it tells you how 
similar your model is to structures in its training set. DOPE's training 
set included only single chain globular proteins. So it *might* work for 
transmembrane proteins (or globular proteins with multiple chains) but 
we can't state that it does with any conviction.

	Ben Webb, Modeller Caretaker
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