On 11/7/13 2:06 AM, pr@tibh@ wrote:
How can i build a homology model using template,my template is a crystal structure of a chimeric protein. though it has a 94% query coverage and 48% identity with my target sequence. sequence alignment of non chimeric protein as a whole is very much identical.Can i use the chimeric crystal structure for modelling?
Yes, that should be fine. Ben Webb, Modeller Caretaker -- http://www.salilab.org/modeller/ Modeller mail list: http://salilab.org/mailman/listinfo/modeller_usage