-- Richard W. Harper Ph.D. Research Professor Indiana University-Purdue University Indianapolis (IUPUI) Department of Chemistry and Chemical Biology 402 N. Blackford Street, LD326 Indianapolis, IN 46202-3274
Attachment:
first_align_modeler.py
Description: application/chimera
>P1;PfFT sequence:PfFT:1 :A : : :farnesyltransferase:P falciparum: : MENRCLYAYKKKFGVSYP---ENLDDEQFEPLNNVMLNMMEQKNFVIEIKD--------- -LEEDAKKYLI----DEKGDI----KNKEKISLINTYYSDRERMLFCLLSSLIEKKEYSF EGYIICSYVIKMNSSYYSAWVYRRKCLKKLNLNLLNDLKFTKYIISDNIKSFQSWFHRRW LIEYIYKMNYRKKNNQRNNECNYNIYIEEGKNIDNKNENLNEYNIDMENNYISSFDDEKN FISSEEEMNSNSSYNIHDNFYNDDDGFISNCDDTDFEEGQENNRNNIYIYEELGNIINNN IFFKNSLLPNEIINIDNFLYEELLYNNCDIFIDMKNYNSWATKTWLIDKFNILQNEYICK KHNIILHEFCFINYLLTIDIYNNSLWVYRYFILNKLSYFHDLAKMQKEIYFCFTYANQFY DNQAIFNYFIHMVFLYIKLYQNASQIKQKNTELNIQCEKKEETYKHDERNIFQIPLVNYI KNELIKIQ--HKSKFVLVFLSQLYS--YNGSYDDEIE--------CYRYLQKYDDFNEHV WKDRIECVQKR--------LKI/ MEKNDSYLLRYHRNKILIHLLYELINYEKYKYTINIDFENETSYNYIENIIKLLFNYIFN LNEDYLDYDTTEKNSINTSFSSCSSDIINEEYLNSIDHDNIFNSLFFNNMYIKEHTINDH CVNEIYKSDNYKTKHLYNNIKEQNVNNVTQNNQVDCSHEDICEKYTEMYNNVTKLSSKQN NIEQETLPTYIQNDNKYISCDIRNNDQLLNNTVFNFYLNCNKNSKTLKEKLKVEKQILTI YYKSFSSTIIDMLLNNPNIHIPDIIIYFLFNHVQKIEDISSYFKNQSYTFDTIHSYIKQI NNMDNKNIINKHTPLHTFEHFKQLYHKEPSENIQNENNINYLNNETEEYNEQYSDSIDIH LHKFINDKEIESTNNLNFNIVEFKSIHIKKEDPFMLSTYKYNFKLNKSNNLLNKFMSILN LQLEKQLHFKFCLDIFFLKNMKLISLEASKPWIFYWCIHSIHILYNTFEIEEKIGKPTFD YIKKCVFLYLNKIKNNDGGFGGGLNQYTHIATTYAAVCVFIYLHDEENNFLSFLDKKKLH SYILKLKCTDGSFRVHINGEIDMRGTYCAISICSMCHILTNEVKKNVEKYILTCQNYEGG FTSEKFQECHGGYSYCALATLCILGKVNKINLKNLTHWLMNKQSNIEGAFMGRTNKLVDS CYSFWMGSIFFLIYEIYILKSILFNKGDITKNNPKGEYVIIEKENEIKDYSKSHELCSEK DINSNTYTENIKSNCFNKYLNQNNDNPNNYLCEQKDVLTYHKMPNEQTKLLHHQNVKNIS KESKIMEDILFFENYKNEYIQKNVLFNENFLKLYLYLCSQNSKGGMKDKPKERIDYYHTC YALSGLSLVQNHLSSLDKKNFKDIQNKDIYNNLNKIHILYNITVDKVYNSYNYF----SP NIPLNQNKINYRTGKGAYLYLKRLLQE* >P1;1JCS structureX:1JCS:55 :A :LAST :B :farnesyltransferase:P falciparum: : ------MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDG FLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSE RAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRV LVEWL----------------------------KDPSQEL-------------------- --------------------------------------------------EFIADILNQ- --------------------------------DAKNYHAWQHRQWVIQEFRLWDN----- -------ELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVP HNESAWNYLKGIL---------------------------------QDRGLSRYP---NL LNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEY WRYIGRSLQSKHSRESDIPASV/ -------------------------------------MASSSSFTY-------------- -------------------YCPPSSSPVWSEPLYSL------------------------ -----------RPEHARERLQDDSVETVT------------------------------- SIEQA----------------------------------------------KVEEKIQEV F--------------------------------------------SSYKFN--------- -------------------------HLVPRLVLQREKHFHYLKRGLRQLTDAYE------ ------------------------------------------------------------ -----------CLD-------------ASRPWLCYWILHSLELL------DEPI--PQIV ATDVCQFLEL--CQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEA--YNVINREKLL QYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGG IGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDG CYSFWQAGLLPLLH---------------------------------------------- ------------------------------------------------RALHAQG----- ------DPALSMSHW---------MFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTC YCLSGLSIAQHFGSG---AMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVP GFEECEDAVTSDPATD-----------*