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Re: [modeller_usage] Objective function scores



On 1/12/21 2:45 PM, Tiglath Moradkhan wrote:
I have a question about objective function scores. Why is it that lower objective function scores are indicative of better models. I've searched online for how objective function scores are computed but the explanation is too technical and I would be very grateful if you could provide a much simpler explanation of the objective function score.
The objective function quantifies how far the current conformation of 
your model is from that implied by your template and known 
stereochemistry. Lower values better satisfy the restraints, but are not 
necessarily "better" models (e.g. because the restraints are derived 
from the template, not the true, unknown, structure). The individual 
terms are described in the 1993 JMB Modeller paper.
	Ben Webb, Modeller Caretaker
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