Hi,
I have a question regarding the zDOPE score. I have read some paper that state this: "The Z-DOPE scores ranged from −1.63 to −1.85, where a score of less than −1 indicates a “reliable” model (i.e., 80% of its Cα atoms are within 3.5 Å of their correct positions)"
I am wondering how is it that a score of less than -1 indicates that 80% of its Cα atoms are within 3.5 Å of their correct positions? How is it possible to know the percent of atoms in the "correct position" based on how small (or not) the z-DOPE is?
What can I say about the magnitude of the negative values besides stating that since the models have negative values they are acceptable?
Best,
Mariana
On 6/18/20 9:48 AM, Mariana GONZALEZ MEDINA wrote: > I have a question regarding the zDOPE score. I have read some paper that > state this: "The Z-DOPE scores ranged from −1.63 to −1.85, where a score > of less than −1 indicates a “reliable” model (i.e., 80% of its Cα atoms > are within 3.5 Å of their correct positions)" > > I am wondering how is it that a score of less than -1 indicates that 80% > of its Cα atoms are within 3.5 Å of their correct positions?
I would say "implies" rather than "indicates". DOPE is a model evaluation function. Of course we don't know the true structure so we can only guess with some degree of confidence (the more negative the score, the more confident I would be) whether a good DOPE score really means a correct model. Benchmarking does show that this is typically the case though; see the DOPE paper.
Ben Webb, Modeller Caretaker
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Mariana GONZALEZ MEDINA -
Modeller Caretaker