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RE: Helix kink

Don't trust modeller ;-) 

You could try to impose ideal helix restraints on the helix and see if
that straightens it.


Andrej Sali, Associate Professor
The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399
tel +1 212 327 7550; lab +1 212 327 7206 ; fax +1 212 327 7540
e-mail ; http://salilab.org

-----Original Message-----
[">mailto:] On Behalf Of Dan
Thomas Major
Sent: Saturday, January 26, 2002 11:40 AM
Subject: Helix kink

In my template protein there is a proline in a helix that causes a kink
in the helix. This proline residue does not occur in the target
protein,but modeller predicts a kink in the target protein as well.
Should I "trust" modeller that there is likely to be a kink or is there
a way of dealing with this... Thanks, Dan