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Re: Loop modeling: old vs. new



Hi,

We do have Windows version in the lab already, and it will be released as
6v2 in a few weeks.

Thanks,
Bozidar


On 17/4/02 6:43 AM, "Mensur Dlakic" <> wrote:

> Hi,
> 
> Has anyone done a real comparison between standalone loop refinment
> procedures in v4.x versus v6.x? Or, for that matter, is any objective
> benchmarking available that compares the two versions? I am one of those
> people who don't like to update the software that already works well, and
> one thing that would definitely motivate me to do so is the improvement in
> loop procedures. On a related note, is there any word about the DOS/Windows
> version of MODELLER?
> 
> What is the lowest target/template identity that has still produced a good
> model of a 80+ residues protein? I am hoping to hear real examples and not
> only a generic answer ("depends on template resolution, alignment
> quality..."). I have made good models in a 10-20% range of indentities, but
> is it realistic to expect a good model with < 10% identity even after the
> iterative realignment? I am often tempted to model proteins falling into
> below 10% category but haven't done it more than 2-3 times, always with
> disappointing results.
> 
> Thanks for your time. May your objectives be high and your objective
> function low,
> 
> Mensur
> 
> ===========================================================================
> | Mensur Dlakic, PhD                    | Tel: (734) 764-3554             |
> | Department of Biological Chemistry    | Fax: (734) 615-3397             |
> | University of Michigan Medical School | http://www.umich.edu/~mensur/   |
> | 5416 Medical Science I                | http://myprofile.cos.com/mensur |
> | Ann Arbor, MI 48109-0606              | E-mail:         |
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> 
>