Subject: Better Prosa Z-scores for models than template
From: Mensur Dlakic <>
Date: Fri, 17 May 2002 16:40:52 -0400 (EDT)
Hi,
I have observed an interesting thing with some recently produced models.
When I evaluate them using Prosa, they all have excellent Z-scores (-5.5 to
-6 for 81 residue protein). The strange part is that the template, also 81
residues long and solved to 2 A, has a Z-score of -4.28. When compared
using Procheck, the template and models are just about indistinguishable in
terms of stereochemistry, even though they share only 17% identity (40%
similarity). Is it "normal" that all models have better Prosa Z-scores than
the template, and what could be the reason for this "improvement"?
Thanks for your time,
Mensur
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| Mensur Dlakic, PhD | Tel: (734) 764-3554 |
| Department of Biological Chemistry | Fax: (734) 615-3397 |
| University of Michigan Medical School | http://www.umich.edu/~mensur/ |
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