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Re: [modeller_usage] RE: How many models to generate?



Hello Frederico Arnoldi!

Thanks for your answer...I have been generating 20 models for my protein of interest, and after evaluating the variability within the family of models, I select one or more models to work with.

This reminds me that I have only an "approximation" of my structure, and also allows me to retain some variability. I then work with these models as one would work with a family of NMR structures.

Does anyone else use more than one model to work with after generating a family with Modeller?

Thank you!

-Charlotte Habegger-Polomat





Frederico Arnoldi wrote:

 Hello Charlotte Habegger-Polomat,

 I am not an expert modeller user, but what I can  "share" about it?
I think the number of models generated depends on available time and computational power you have to carry it. I usually generate between 100 and 200, and select that model with the lowest "current energy".
Probably somebody could discuss it better, anyway, I tried ;)

Frederico Arnoldi
UNESP - Rio Claro - Brazil