[modeller_usage] Fwd: More than one Proline in helix!
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Subject: [modeller_usage] Fwd: More than one Proline in helix!
From: Raghu Bhagavat <>
Date: Tue, 10 Nov 2009 10:56:11 +0530
---------- Forwarded message ---------- From: Raghu Bhagavat<">>
Date: Mon, Nov 9, 2009 at 10:53 PM Subject: More than one Proline in helix! To: ">
hello.... I modeled a protein using 2 templates in Modeller9...1-312 residues w.r.t one protein and the next 65 resdiues w.r.t another protein....The template selection is done carefully and both the templates share a good homology with my query sequnce....
But, i have got prolines in helix which i doubt about its existence.....Its a pretty long helix in which 3 prolines are present and 2 of them are in the middle of long helix.....There is an immediate loop following this and then another helix having 2 Prolines....
Can anybody suggsest how modeler came up with such a model having Prolines in helix?? Is it valid ?? how stable is it?? has anybody encountered with the same Proline issue with any other protein?