| Couldn't one approximate template weighting in a "dirty" way by using multiple copies of a template in the alignment file? i.e. if template t1 is included in the alignment twice (or maybe even just named twice in the 'knowns' list in the script, not sure about this) and t2 is used only once, then effectively the t1 restraint values have twice the probability of the t2 restraint values (everything else being equal). Ben, do you think this would work? Of course it is important to point out that individual t1 and t2 restraints in the example are probably not being weighted equally anyway (because of the varying degrees of similarity between t1, t2, and the target, at different points in the sequence/structure). So maybe the important questions is WHY you would like to change the weighting of the restraints that MODELLER would do automatically? Best, Roberto -- Roberto Sanchez, Ph.D. Associate Professor Department of Structural and Chemical Biology Mount Sinai School of Medicine Box 1677, 1425 Madison Avenue, New York, NY 10029 phone +1 (212) 659 8648, fax +1 (212) 659 8232 http://sanchezlab.org/ On May 27, 2010, at 2:09 PM, Modeller Caretaker wrote:
|