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Re: [modeller_usage] about model rank



On 3/1/11 12:23 AM, Ashish Runthala wrote:
NEVER USE DOPE ALONE TO RANK MODELS. ONLY DOPE IS NOT A GOOD SELECTION MEASURE.
Such a strong statement needs to be backed up by a publication... 
particularly given that it is contradicted by both your next sentence 
and our own study (Prot Sci 17, 1881-1893, 2008).
Use normalized_dope
Normalized DOPE is derived from the raw DOPE score. Thus the ranking of 
models, given the same sequence, will be the same with DOPE or 
normalized DOPE.
However, since raw DOPE is an "energy", you should certainly not use it 
to rank models that differ in sequence. For that, normalized DOPE would 
be more appropriate.
or GDT to rank models/Clusters/Hybrid Models.
GDT is a structural measure, like RMSD, so it requires another structure 
to compare against. This makes it useless for assessing comparative 
models unless you already know the answer (as in CASP).
	Ben Webb, Modeller Caretaker
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