UCSF Laboratory of Andrej Sali QB3

Integrative Structural Biology

We aim to develop and apply computational methods for integrative determination of the structures and dynamics of macromolecular assemblies, in turn informing the function and evolution of these systems as well as how to modulate them. The broad goal is to contribute to a predictive spatiotemporal model of the cell. This goal is being achieved by a formal integration of experiment, physics, and statistical inference, spanning all relevant size and time scales. Our computational methods are implemented in the open source Integrative Modeling Platform package (IMP). This research enhances the discovery of general principles that underlie all cellular processes, which in turn also facilitates drug discovery.


Congratulations to Sara:
Sara Calhoun received the Mel Jones Excellence in Graduate Student Research Award !

Congratulations to Adrian:
Adrian Stecula is a recipient of an AFPE Pre-Doctoral Award in Pharmaceutical Science!

Congratulations to Ilan:
Ilan Chemmama has received a 3 year NSF fellowship !

Congratulations to Kate:
Kate Stafford has received a 3 year NRSA fellowship !

Congratulations to Adrian:
Adrian is a recipient of the PhRMA fellowship in Pharmacology/Toxicology !

Congratulations to Jeremy Horst: His recent publication was highlighted by the Structural Biology Knowledgebase.

Workshop on Theoretical Model Archiving, Validation and PDBx/mmCIF Data Exchange Format.
October 21 & 22, 2013
Rutgers University, NJ.

Congratulations to Natalia:
Natalia is a recipient of a 2013-2014 Merit Fellowship Award - an Achievement Rewards for College Scientists (ARCS) Scholarship !

Congratulations to SJ:
The paper "Structure, Dynamics, Evolution, and Function of a Major Scaffold Component in the Nuclear Pore Complex", P. Sampathkumar, et al, has been published in Structure! We also congratulate Graham Johnson of UCSF for the great cover image!

Congratulations to Javi:
We wish him the best in his position as Bioinformatics Analyst at Cypher Genomics!

Congratulations to Avner:
We wish him the best in his new position as Assistant Professor at Mount Sinai Hospital !

Congratulations to Jeremy and Peter:
Jeremy won the Frank M. Goyan Award for Excellence in Physical Chemistry and Peter has received the 2012 School of Pharmacy Research Award !

Congratulations to Keren:
The paper "Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach", K. Lasker, et al, has been accepted for publication in PNAS !

Congratulations to Riccardo on the news of his Swiss National Science Foundation fellowship!!

Congratulations to Avner:
The paper "Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET", A. Schlessinger, E. Geier, H. Fan, J. Irwin, B. Shoichet, K. Giacomini, A. Sali, has been accepted for publication in PNAS !

Congratulations to Peter on being awarded the Howard Hughes Medical Institutes Predoctoral Fellowship!!

Congratulations Charles on being awarded the NSF Graduate Research Fellowship!!

Selected Publications

  • F. Alber, S. Dokudovskaya, L. Veenhoff, W. Zhang, J. Kipper, D. Devos, A. Suprapto, O. Karni, R. Williams, B.T. Chait, M.P Rout, A. Sali. "Determining the architectures of macromolecular assemblies" Nature 450, 683-694, 2007. PubMed PDF ...
  • D. Russel, K. Lasker, B. Webb, J. Velazquez-Muriel, E. Tjioe, D. Schneidman-Duhovny, B. Peterson, A. Sali. "Putting the pieces together: integrative structure determination of macromolecular assemblies" PLoS Biology 10, e1001244, 2012. PubMed PDF
  • K. Lasker, F. Forster, S. Bonn, et al "Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach." PNAS 109, 1380-1387, 2012. PubMed PDF
  • A. Sali et al. "Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop." Structure 23, 1156-1167, 2015. PUBMED PDF


<img src="img/gallery/image1.gif" alt="IMAGE of NUP">
Andrej Sali, PhD, Professor, Department of Bioengineering and Therapeutic Sciences; Department of Pharmaceutical Chemistry; School of Pharmacy, University of California at San Francisco, UCSF MC 2552, Mission Bay, Byers Hall, 1700 4th Street, Suite 503B, San Francisco, CA 94143, Tel +1 (415) 514-4227, Fax +1 (415) 514-4231, 4234, , Web https://salilab.org