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FW: modeling problem




------ Forwarded Message
From: Feng Cui <>
Date: Tue, 29 Jul 2003 21:28:31 -0500 (CDT)
To: 
Subject: modeling problem



Sir,

I am doing a project on homology modeling using Modeller. My question is
following:

The target sequence has 5 domains (519aa in total). I can find a template
structure for the first two domains (Part I), and another template structure
for
the last three domains (Part II). Part I and Part II are separated by a gap
with
7 amino acids in length. fortunately i found a piece of peptide (9 aa) which
can
fill the gap (in 7/9 indentity) and anchored on the Part I and II. can i
made a
model based on the "contig" piece by piece? should i trust the model, e.g.
the
relative orientation of Part I and Part II?

have you met a similar problem? any suggestion would be appreciated. or you
may
forward the message to the discussion forum. thank you very much for your
help.

Feng Cui  






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