[Date Prev][Date Next][Thread Prev][Thread Next][Date Index][Thread Index]
Re: [modeller_usage] homology modeling
On 7/20/18 8:59 AM, Mohammad Goodarzi wrote:
I have a WT protein which I got the structure from the PDB.
I have a mutation happing on a single point amino acid.
I want to see how this mutation influence on specific domian. I want to
know if I am doing it right or not
...
what step should I follow and or which script should I use ?
This is simple comparative modeling where your target sequence is
identical to your template sequence except for one residue. A script
similar to that at https://salilab.org/modeller/9.20/manual/node16.html
should work just fine. Alternatively, you can try the mutate model
script at https://salilab.org/modeller/wiki/Mutate%20model
Ben Webb, Modeller Caretaker
--
modeller-care@salilab.org https://salilab.org/modeller/
Modeller mail list: https://salilab.org/mailman/listinfo/modeller_usage