Andrej Sali Lab

Our Resources

Bioinformatics, Computational Structural Biology

We are using computation grounded in the laws of physics and evolution to study the structure and function of proteins. We aim to improve and apply methods for:

predicting the structures of proteins;
determining the structures of macromolecular assemblies;
annotating the functions of proteins using their structures.

This research enhances the impact of genome sequencing, structural genomics, and functional genomics on biology and medicine.

News

Congratulations to Natalia:
Natalia is a recipient of a 2013-2014 Merit Fellowship Award - an Achievement Rewards for College Scientists (ARCS) Scholarship !

Congratulations to SJ:
The paper "Structure, Dynamics, Evolution, and Function of a Major Scaffold Component in the Nuclear Pore Complex", P. Sampathkumar, et al, has been published in Structure! We also congratulate Graham Johnson of UCSF for the great cover image!

Congratulations to Javi:
We wish him the best in his position as Bioinformatics Analyst at Cypher Genomics!

Congratulations to Avner:
We wish him the best in his new position as Assistant Professor at Mount Sinai Hospital !

Congratulations to Jeremy and Peter:
Jeremy won the Frank M. Goyan Award for Excellence in Physical Chemistry and Peter has received the 2012 School of Pharmacy Research Award !

Congratulations to Keren:
The paper "Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach", K. Lasker, et al, has been accepted for publication in PNAS !

Congratulations to Riccardo on the news of his Swiss National Science Foundation fellowship!!

Congratulations to Avner:
The paper "Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET", A. Schlessinger, E. Geier, H. Fan, J. Irwin, B. Shoichet, K. Giacomini, A. Sali, has been accepted for publication in PNAS !

Congratulations to Peter on being awarded the Howard Hughes Medical Institutes Predoctoral Fellowship!!

Congratulations Charles on being awarded the NSF Graduate Research Fellowship!!

Congratulations to Dave:
D. Barkan, D. Hostetter, S. Mahrus, U. Pieper, J. Wells, C. Craik, A. Sali. Prediction of Protease Substrates using Sequence and Structure Features. Bioinformatics 26, 1714-1722, 2010.

The Chimera - Modeller module is now available in the daily builds of UCSF Chimera!

Congratulations Peter on being awarded a 2010-11 Chancellor's Graduate Research Fellowship!!

Selected Publications

F. Alber, S. Dokudovskaya, L. Veenhoff, W. Zhang, J. Kipper, D. Devos, A. Suprapto, O. Karni, R. Williams, B.T. Chait, M.P Rout, A. Sali. "Determining the architectures of macromolecular assemblies" Nature 450, 683-694, 2007.
D. Russel, K. Lasker, B. Webb, J. Velazquez-Muriel, E. Tjioe, D. Schneidman-Duhovny, B. Peterson, A. Sali. "Putting the pieces together: integrative structure determination of macromolecular assemblies" PLoS Biology 10, e1001244, 2012.
K. Lasker, F. Forster, S. Bonn, et al "Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach." PNAS 109, 1380-1387, 2012.
J.A. Velazquez-Muriel, K. Lasker, D. Russel, J. Phillips, B. Webb, D. Schneidman-Duhovny, A. Sali. "Assembly of macromolecular complexes by satisfaction of spatial restraints from electron microscopy images." PNAS 109, 18821-18826, 2012.

Gallery