Andrej Sali Lab

Our Resources

Bioinformatics, Computational Structural Biology

We are using computation grounded in the laws of physics and evolution to study the structure and function of proteins. We aim to improve and apply methods for:

predicting the structures of proteins;
determining the structures of macromolecular assemblies;
annotating the functions of proteins using their structures.

This research enhances the impact of genome sequencing, structural genomics, and functional genomics on biology and medicine.

News

Go Dave! Congratulations on your UC Cancer Research Coordinating Committee Fellowship

Andrej becomes Director of QB3 at UCSF

Congratulations to Marc:
L. Ortí, R.J. Carbajo, U. Pieper, N. Eswar, S.M. Maurer, A.K. Rai, G. Taylor, M.H. Todd, A. Pineda-Lucena, A. Sali, M.A. Marti-Renom. A kernel for open source drug discovery in tropical diseases. PLoS Neglected Tropical Diseases 3, e418, 2009.

Congratulations to Mark:
M.E. Peterson, F. Chen, J.G. Saven, D.S. Roos, P.C. Babbitt, A. Sali. Evolutionary constraints on structural similarity in orthologs and paralogs. Protein Science, in press.

Congratulations to Daniel, Keren, Javi, Jeremy and Dina:
D. Russel, K. Lasker, J. Phillips, D. Schneidman-Duhovny, J.A. Velazquez- Muriel, A. Sali. The structural dynamics of macromolecular complexes. Curr. Opin. Cell. Biol. 21, 1-12, 2009.

Selected Publications

F. Alber, S. Dokudovskaya, L. Veenhoff, W. Zhang, J. Kipper, D. Devos, A. Suprapto, O. Karni, R. Williams, B.T. Chait, M.P Rout, A. Sali. "Determining the architectures of macromolecular assemblies" Nature 450, 683-694, 2007.
C.V. Robinson, A. Sali, W. Baumeister. "Molecular sociology of the cell" Nature 450, 973-982, 2007.
F.P. Davis, D.T. Barkan, N. Eswar, J.H. McKerrow, A. Sali. "Host-Pathogen Protein Interactions Predicted by Comparative Modeling" Protein Science 16, 2585-2596, 2007.
K. Lasker, M. Topf, A. Sali, H. Wolfson. Inferential optimization for simultaneous fitting of multiple components into a cryoEM map of their assembly. Journal of Molecular Biology, 388, 180-194, 2009.

Gallery