Organization: University of California - San Francisco
Yes, the modweb models are currently based on a single template only. A
future version of ModWeb will return models based on multiple templates. So
for now, using MODELLER in a manual fashion will probably result in more
accurate models depending on the quality of the alignments and templates.
Eswar.
---
Eswar Narayanan, Ph.D
Mission Bay Genentech Hall
600 16th Street, Suite N474Q
University of California, San Francisco
San Francisco, CA 94143-2240 (CA 94158 for courier)
Tel +1 (415) 514-4233; Fax +1 (415) 514-4231
http://www.salilab.org/~eashwar
> -----Original Message-----
> From: [mailto:modeller_usage-
> ] On Behalf Of
> Sent: Monday, March 15, 2004 12:34 PM
> To:
> Subject: [modeller_usage] ModWeb question
>
> Dear All
>
> When sending a query sequence to modweb, this will suggest a
> tridimensional
> model homology-related to a specific template (which has a experimental
> structure determined). The question is ;
> When using Modeller stand alone we can make an alignment between our query
> sequence and several templates in order to better define regions of
> structural
> similarity. ModWeb works also in this way ? I mean, the model contructed
> for the
> query sequence is based lonely in one template ? So, is correct to assume
> that
> the ModWeb procedure is less accurate than the modeller when used
> "manually" due
> the one-template basis of calculation?
> Thanks in advance
>
> Frank Alarcon
>
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