I have a windows XP SP2 IBM laptop with plenty of memory (512MB RAM) and
processing speed. When I try to model a protein domain of about 750 residues
(with a multiple alignment of only two sequences, the target and the strucutre
sequence), the program runs for about 20-30 seconds and then I get this error:
C:\Program Files\Modeller7v7\examples\tutorial-model>mod7v7 Toms-Initial
forrtl: severe (170): Program Exception - stack overflow
This means that Modeller has exceeded the stack space limit. This a
constant, set when the Modeller binary was linked, so it won't help if
you add more memory to your machine.
Ultimately, this problem will be fixed by making Modeller use less stack
space, but until then the simple solution is to increase the stack
limit. If you have Visual C++ (and know what you're doing) then you can
use Microsoft's EDITBIN utility to do this.
Alternatively, you can download just such a 'fixed' binary from the
Modeller downloads page: