Summary

This page shows a number of applications of IMP to biological systems. They can be adapted to tackle other similar problems, or to add new input data to an existing system.

Each system links to its web page, where all the input files can be found, complete with running instructions. Most systems are permanently archived (via DOIs) at Zenodo; newer systems are also deposited at PDB-Dev.

Every system is periodically tested with the latest version of IMP to make sure it works. The most recent version of IMP that it works with is shown below (or see all builds).

See the IMP manual for information on adding a new system to this page.

All systems with the PMI1 tag are shown. [Show all systems]

Show only systems with tag
affinity purification allostery analysis benchmark Brownian dynamics C3 C3b chemical crosslinks chromatin coiled-coils COSMIC cryo-EM cysteine crosslinks drosophila melanogaster EM EM class average EM density map endogenous complex escape mutations FoXS FRET glycosylation iC3 in-vivo FRET ISAMBARD mass spectrometry model MODELLER multi-state MultiFit nanobodies native mass spec NMR pEMAP PMI PMI1 quantitative crosslinking SAXS SEC-MALLS shape-complementarity TADs threading X-ray yeast two-hybrid
thumbnail

26S-PIPs complex PubMed logo

Modeling the structures of complexes between the 26S proteasome and proteasome interacting proteins [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18
thumbnail

40S•eIF1•eIF3 Complex PubMed logo

Determination of the molecular architecture of the 40S•eIF1•eIF3 translation initiation complex [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18
thumbnail

Human Complement PubMed logo PDB-Dev

Human complement modeling [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18
thumbnail

Exosome modeling PubMed logo PDB-Dev

Modeling exosome complexes from cross-link MS data [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18
thumbnail

Integrin

Example of using IMP and PMI to model integrin [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18
thumbnail

Mediator Complex PubMed logo PDB-Dev

Modeling of the yeast Mediator complex [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18
thumbnail

Nuclear Pore Complex PubMed logo PDB-Dev

Modeling of the yeast Nuclear Pore Complex [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18
thumbnail

Nup82 Complex PubMed logo PDB-Dev

Modeling of the Nup82 subcomplex of the Nuclear Pore Complex [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18
thumbnail

Nup84 Complex PubMed logo PDB-Dev

Modeling of the Nup84 subcomplex of the Nuclear Pore Complex [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18
thumbnail

Modeling of Pom152 PubMed logo PDB-Dev

Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18
thumbnail

SEA Complex PubMed logo

Modeling of the SEA complex [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18
thumbnail

TFIIH complex PubMed logo

Modeling of the TFIIH complex using chemical cross-links and electron microscopy (EM) density maps [more...]

Last worked with IMP stable release (main branch): 2.20.1
Last worked with IMP nightly build (develop branch): 2023-12-18