Summary

This page shows a number of applications of IMP to biological systems. They can be adapted to tackle other similar problems, or to add new input data to an existing system.

Each system links to its web page, where all the input files can be found, complete with running instructions. Most systems are permanently archived (via DOIs) at Zenodo; newer systems are also deposited at PDB-Dev.

Every system is periodically tested with the latest version of IMP to make sure it works. The most recent version of IMP that it works with is shown below (or see all builds).

See the IMP manual for information on adding a new system to this page.

Show only systems with tag
affinity purification allostery analysis benchmark Brownian dynamics C3 C3b chemical crosslinks chromatin coiled-coils COSMIC cryo-EM cryo-ET cysteine crosslinks drosophila melanogaster EM EM class average EM density map endogenous complex escape mutations FCS FoXS FRET glycosylation iC3 in-vivo FRET ISAMBARD mass spectrometry model MODELLER multi-state MultiFit nanobodies native mass spec NMR pEMAP PMI PMI1 quantitative crosslinking SAXS SEC-MALLS shape-complementarity spatiotemporal TADs threading X-ray yeast two-hybrid
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26S-PIPs complex PubMed logo

Modeling the structures of complexes between the 26S proteasome and proteasome interacting proteins [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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40S•eIF1•eIF3 Complex PubMed logo

Determination of the molecular architecture of the 40S•eIF1•eIF3 translation initiation complex [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Integrative structures of the human Cop9 signalosome PubMed logo PDB-Dev

Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Human Complement PubMed logo PDB-Dev

Human complement modeling [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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AllosMod benchmark PubMed logo

Benchmark of the AllosMod method [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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DNA-PKcs PubMed logo PDB-Dev

Integrative threading of protein structure using secondary structure elements [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Model of Ecm29-proteasome complex PubMed logo PDB-Dev

Regulation of 26S proteasome via interaction with Ecm29 [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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eIF3 Modeling PubMed logo

Data and scripts to model eIF3 from mass spec data [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Exocyst Complex PubMed logo PDB-Dev

Integrative Modeling of Yeast Exocyst Complex [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Exosome modeling PubMed logo PDB-Dev

Modeling exosome complexes from cross-link MS data [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Modelling of a region of the fly genome

Example of using IMP to model a region of the Fly genome https://integrativemodeling.org/systems/ [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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FRET Benchmark PubMed logo

Benchmark of the FRET<sub>R</sub> Bayesian restraint [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Glycophorin

Example of using IMP and PMI to model glycophorin [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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GroEL PubMed logo

Modeling of the bacterial molecular chaperone GroEL using 3D EM data and cnmultifit [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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γTuSC-Spc110 Complex PubMed logo PDB-Dev

Integrative model of the γTuSC-Spc110 complex [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Integrin

Example of using IMP and PMI to model integrin [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Mediator Complex PubMed logo PDB-Dev

Modeling of the yeast Mediator complex [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Mass Spec Benchmark PubMed logo

Benchmark for the sampling procedure used in the Mass Spec paper [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Nanobody epitopes on SARS-CoV-2 spike protein PubMed logo

Integrative modeling of nanobody binding modes to the SARS-CoV-2 Spike protein [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Integrative structures of the Nef-CD4-AP2 complex PubMed logo PDB-Dev

Integrative structure of the Nef-CD4(CD)-AP2(Δμ2-CTD) complex [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Nuclear Pore Complex PubMed logo PDB-Dev

Modeling of the yeast Nuclear Pore Complex [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Brownian Dynamics simulations of yeast NPC FG repeats PubMed logo PDB-Dev

Brownian Dynamics simulations of yeast NPC FG repeats [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Nup133 PubMed logo PDB-Dev

Modeling of the Nup133 subunit of the Nuclear Pore Complex [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Nup82 Complex PubMed logo PDB-Dev

Modeling of the Nup82 subcomplex of the Nuclear Pore Complex [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Nup84 Complex PubMed logo PDB-Dev

Modeling of the Nup84 subcomplex of the Nuclear Pore Complex [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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NuRD subcomplexes

Integrative modeling of NuRD sub-complexes [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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PDE6 PubMed logo

Modeling of the phosphodiesterase (PDE6) [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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PhoQ PubMed logo

Multi-state modeling of the PhoQ two-component system [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Postmitotic nuclear pore complex assembly pathway

Code for spatiotemporal modeling of the NPC Assembly Pathway [more...]

Last worked with IMP nightly build (develop branch): 2024-12-05
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Pol II (G) complex PubMed logo PDB-Dev

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1 [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Modeling of Pom152 PubMed logo PDB-Dev

Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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SAXS Merge benchmark PubMed logo

Benchmark of the SAXS Merge method [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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SEA Complex PubMed logo

Modeling of the SEA complex [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Smc5/6-Nse2/5/6 complex PubMed logo PDB-Dev

Integrative modeling of the Smc5/6-Nse2/5/6 complex using comparative modeling and chemical crosslinks. [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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Spindle Pole Body core PubMed logo

Modeling of the yeast spindle pole body (SPB) [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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TFIIH complex PubMed logo

Modeling of the TFIIH complex using chemical cross-links and electron microscopy (EM) density maps [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05
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PMI RNAPII Modeling Tutorial

Tutorial that demonstrates the modeling of RNA Polymerase II using Electron Microscopy density and chemical crosslinks [more...]

Last worked with IMP stable release (main branch): 2.21.0
Last worked with IMP nightly build (develop branch): 2024-12-05

warning The following systems are still under development and have not yet been tested against the public release of IMP:

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Integrative structures of the A3G-CRL5-Vif-CBFb complex PubMed logo PDB-Dev

Integrative structure determination of the A3G-CRL5-Vif-CBFβ complex [more...]

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MultiFoXS benchmark

Benchmark of the MultiFoXS method [more...]

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Comprehensive structure and functional adaptations of the yeast nuclear pore complex PubMed logo PDB-Dev

Integrative structure determination of the yeast NPC [more...]

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Genetic interaction mapping informs integrative structure determination of protein complexes PubMed logo

Integrative Structure Determination using data from point mutant epistatic miniarray profile [more...]

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Sampling exhaustiveness benchmark

Benchmark for sampling exhaustiveness method [more...]