15 Jul
2021
15 Jul
'21
5:17 p.m.
On 7/2/21 6:37 AM, Andrea Graziadei wrote: > I am modeling a multistate system in PMI using > CrossLinkingMassSpectrometryRestraint in imp-2.15, and trying to > adapt imp-sampcon for the purpose. ... > After running replica exchange, i am trying to extract distances for > my crosslinks (in theory 2 per protein copy, one in state 0 and one in > state 1).
If I'm understanding your setup correctly, each crosslink need only be satisfied by one of the two states, so you would only get one distance.
Ben
--
ben@salilab.org https://salilab.org/~ben/
"It is a capital mistake to theorize before one has data."
- Sir Arthur Conan Doyle