Re: [IMP-users] weights testing

On 4/26/19 3:40 AM, Andrea Graziadei wrote: > I am continuing to working with IMP/PMI for integrative modeling of a > protein complex using EM and crosslinking information. Ultimately, as in > the tutorial, I have 4 sets of restraints: excluded volume, > connectivity, crosslinks and gaussian. > > I would like to explore what weights to set.

Generally it shouldn't be necessary to modify the weights, except for possibly the EM restraint. There thus isn't really a protocol for optimizing the weights. Ideally each restraint would be Bayesian in nature such that weights are entirely unnecessary, although this isn't yet the case for EM.

Ben